The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

Complex, multistep biochemical reactions that routinely take place in our cells require high
concentrations of enzymes, substrates, and other structural components to proceed …

Expansions of short nucleotide repeats produce several neurological and neuromuscular
disorders including Huntington disease, muscular dystrophy, and amyotrophic lateral …

Nuclear speckles (NS) are among the most prominent biomolecular condensates. Despite
their prevalence, research on the function of NS is virtually restricted to colocalization …

Nuclear speckles are dynamic membraneless bodies located in the cell nucleus. They
harbor RNAs and proteins, many of which are splicing factors, that together display complex …

Phase-separated membraneless bodies play important roles in nucleic acid biology. While
current models for the roles of phase separation largely focus on the compartmentalization …

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Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene
(HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We …

Fluorogenic RNA aptamers are valuable tools for cell imaging, but they still suffer from
shortcomings such as easy degradation, limited photostability, and low fluorescence …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …