The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant
proteins result in perturbations of many cellular components. MDs have been associated …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

Calpains are members of a large family of Ca2+-dependent proteolytic enzymes. Some are
tissue-specific; others are ubiquitous. Poised to digest numerous intracellular proteins, their …

Making the diagnosis of a particular type of limb girdle muscular dystrophy (LGMD) can
appear challenging. In fact, various clues from the way the patient presents, and the results …

Limb-girdle muscular dystrophies (LGMD) are a heterogeneous group of disorders, which
has led to certain investigators disputing its rationality. The mutual feature of LGMD is limb …

Background Muscle wasting is observed in the course of many diseases and also during
physiological conditions (disuse, ageing). Skeletal muscle mass is largely controlled by the …

Titin, the largest protein known to date, has been linked to sarcomere assembly and function
through its elastic adaptor and signaling domains. Titin's M-line region contains a unique …

Using molecular dynamics simulations, we have explored the mechanical strength of the titin
Z1Z2-telethonin complex, namely, its ability to bear strong forces such as those encountered …

Adult skeletal muscles in vertebrates are composed of different types of myofibers endowed
with distinct metabolic and contraction speed properties. Genesis of this fiber-type …