Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

Highlights•Multi-segmented dsRNA viruses package+ RNAs prior to dsRNA synthesis.•The
three Cystoviridae+ RNAs are sequentially packaged into a procapsid.•Reoviridae …

Mammalian orthoreoviruses (reoviruses) are highly tractable experimental models for
studies of double-stranded (ds) RNA virus replication and pathogenesis. Reoviruses infect …

Entry of reovirus virions has been well studied in several tissue culture systems. After
attachment to junctional adhesion molecule A (JAM-A), virions undergo clathrin-mediated …

Like most viruses that replicate in the cytoplasm, mammalian reoviruses assemble
membranous neo-organelles called inclusions that serve as sites of viral genome replication …

Viruses require the host translational apparatus to synthesize viral proteins. Host stress
response mechanisms that suppress translation, therefore, represent a significant obstacle …

Mammalian reoviruses are thought to assemble and replicate within cytoplasmic,
nonmembranous structures called viral factories. The viral nonstructural protein μNS forms …

Piscine orthoreovirus (PRV) is associated with heart-and skeletal muscle inflammation
(HSMI) of farmed Atlantic salmon (Salmo salar). We have performed detailed sequence …

Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as
sites of viral genome replication and particle assembly. These highly specialized structures …

Infection with many mammalian orthoreovirus (MRV) strains results in shutoff of host, but not
viral, protein synthesis via protein kinase R (PKR) activation and phosphorylation of …