Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease
characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed …

Observational studies of necrotic core progression identify intraplaque hemorrhage as a
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

The presence of areas of hypoxia is a prominent feature of various inflamed, diseased
tissues, including malignant tumors, atherosclerotic plaques, myocardial infarcts, the synovia …

Objectives: We sought to examine the presence of hypoxia in human carotid atherosclerosis
and its association with hypoxia-inducible transcription factor (HIF) and intraplaque …

Specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins are formed by
the consecutive action of 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic …

The clinical complications of atherosclerosis are caused by thrombus formation, which in
turn results from rupture of an unstable atherosclerotic plaque. The formation of …

Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …