Iron overload is a pathological condition resulting from a congenital impairment of its
regulation, increased intestinal iron absorption secondary to bone marrow erythroid …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Purpose β-Thalassemia is an inherited blood disorder characterized by reduced or no
production of adult hemoglobin. Systematic identification of the burden of β-thalassemia with …

Iron homeostatic mechanisms are key to the pathophysiology of transfusional iron overload
(TIO). In humans, these mechanisms are best adapted to increasing iron acquisition in …

The aims of this review are to highlight the mechanisms and consequences of iron
distribution that are most relevant to transfused sickle cell disease (SCD) patients and to …

Background Metals are pervasive throughout biological processes, where they play
essential structural and catalytic roles. Metals can also exhibit deleterious effects on human …

The liver is the organ for iron storage and regulation; it senses circulating iron
concentrations in the body through the BMP‐SMAD pathway and regulates the iron intake …

Sickle cell disease (SCD) or homozygous sickle cell anemia is the most common inherited
disorder of erythrocytes, characterized by the presence of pathologic hemoglobin S (HbS). A …

Liver involvement is often observed in several hematological disorders, resulting in
abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms …

Sickle hepatopathy is an umbrella term describing various pattern of liver injury seen in
patients with sickle cell disease. The disease is not uncommon in India; in terms of …