[HTML][HTML] Designing degradable hydrogels for orthogonal control of cell microenvironments

PM Kharkar, KL Kiick, AM Kloxin - Chemical Society Reviews, 2013 - pubs.rsc.org
Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …

Oxime ligation: a chemoselective click‐type reaction for accessing multifunctional biomolecular constructs

S Ulrich, D Boturyn, A Marra… - … –A European Journal, 2014 - Wiley Online Library
There is a growing need for biocompatible click reactions in order to prepare multifunctional
conjugates, which are valuable molecules for innovative biomedical applications. In this …

Click chemistry in materials science

W Xi, TF Scott, CJ Kloxin… - Advanced Functional …, 2014 - Wiley Online Library
Despite originating only a little more than a decade ago, click chemistry has become one of
the most powerful paradigms in materials science, synthesis, and modification. By …

Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry

CH Wong, SC Zimmerman - Chemical Communications, 2013 - pubs.rsc.org
The concept of orthogonality has been applied to many areas of chemistry, ranging from
wave functions to chromatography. But it was Barany and Merrifield's orthogonal protecting …

“Click”-inspired chemistry in macromolecular science: matching recent progress and user expectations

P Espeel, FE Du Prez - Macromolecules, 2015 - ACS Publications
This year, it has been a decade that the concept of “click” chemistry was pioneered in
polymer and material science by the exploration of the synthetic scope of copper-catalyzed …

The emergence of oxime click chemistry and its utility in polymer science

J Collins, Z Xiao, M Müllner, LA Connal - Polymer Chemistry, 2016 - pubs.rsc.org
The synthesis of new, highly functional and dynamic polymeric materials has risen
dramatically since the introduction of click chemistry in 2001. This diverse set of reactions …

Metal‐free click chemistry reactions on surfaces

J Escorihuela, ATM Marcelis… - Advanced Materials …, 2015 - Wiley Online Library
In the last decade, interest in the functionalization of surfaces and materials has increased
dramatically. In this regard, click chemistry deserves a central focus because of its mild …

Metal‐mediated functionalization of natural peptides and proteins: Panning for bioconjugation gold

J Ohata, SC Martin, ZT Ball - Angewandte Chemie International …, 2019 - Wiley Online Library
Selective modification of natural proteins is a daunting methodological challenge and a
stringent test of selectivity and reaction scope. There is a continued need for new reactivity …

Electron-beam lithography for patterning biomolecules at the micron and nanometer scale

CM Kolodziej, HD Maynard - Chemistry of materials, 2012 - ACS Publications
This review summarizes the use of electron beam (e-beam) lithography to pattern
biomolecules on surfaces. The focus is on approaches that employ poly (ethylene …

Surface patterning of hydrogel biomaterials to probe and direct cell–matrix interactions

BG Munoz‐Robles, I Kopyeva… - Advanced Materials …, 2020 - Wiley Online Library
Due to their mechanical and structural similarity to native tissues, hydrogel biomaterials
have gained tremendous popularity for applications in 3D tissue culture, therapeutic …