Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans
(PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and …

The tumor microenvironment (TME) is a dynamic and complex matter shaped by
heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan …

Background Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells
(LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to …

The complex interplay between malignant cells and the cellular and molecular components
of the tumor stroma is a key aspect of cancer growth and development. These tumor–host …

The lymphatic system has received increasing scientific and clinical attention because a
wide variety of diseases are linked to lymphatic pathologies and because the lymphatic …

Lymphatic metastasis represents the main route of tumour cell dissemination in oral
squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting …

Abstract Objective Breast Cancer (BC) is one of the deadliest diseases in women, causing
thousands of deaths annually despite the advent of high-throughput genomic platforms in …

KRAS mutations are detected in numerous human cancers, but there are few effective drugs
for KRAS‐mutated cancers. Transporters for amino acids and glucose are highly expressed …

Copy number alterations detected by comparative genomic hybridization (CGH) can lead to
the identification of novel cancer‐related genes. We analyzed chromosomal aberrations in a …

Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic
vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic …