Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …

The activation of carboxylic acids to thioesters plays an important role in biology. However,
biochemical studies and biotechnological applications are hampered by a general lack of …

Abstract N‐alkanoyl‐N‐methylglucamides (MEGAs) are non‐toxic surfactants widely used
as commercial ingredients, but more sustainable syntheses towards these compounds are …

ATP recycling systems are required to avoid the addition of stoichiometric quantities of
cofactor and facilitate industrial implementation of ATP-dependent enzymes. One factor that …

Hydrolases are well-known for hydrolyzing esters, amides, carbamates, peptides, or acid
anhydrides in the presence of water. However, some of them are also capable of catalyzing …

Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of
this technology is yet to be unlocked. Accessing new chemistries and expanding the scope …