Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
[HTML][HTML] Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues
Aldehyde oxidase (AOX) is a cytosolic drug-metabolizing enzyme which has attracted
increasing attention in drug development due to its high hepatic expression, broad substrate …
increasing attention in drug development due to its high hepatic expression, broad substrate …
Recent developments in predicting CYP-independent metabolism
NV Dhuria, B Haro, A Kapadia, KA Lobo… - Drug metabolism …, 2021 - Taylor & Francis
As lead optimization efforts have successfully reduced metabolic liabilities due to
cytochrome P450 (CYP)-mediated metabolism, there has been an increase in the frequency …
cytochrome P450 (CYP)-mediated metabolism, there has been an increase in the frequency …
Drug clearance by aldehyde oxidase: can we avoid clinical failure?
Despite increased awareness of aldehyde oxidase (AO) as a major drug-metabolising
enzyme, predicting the pharmacokinetics of its substrates remains challenging. Several drug …
enzyme, predicting the pharmacokinetics of its substrates remains challenging. Several drug …
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques
Y Uno, S Uehara, N Murayama, H Yamazaki - Xenobiotica, 2021 - Taylor & Francis
The cynomolgus macaque is a non-human primate species widely used in drug metabolism
studies. Despite the importance of genetic polymorphisms in cytosolic aldehyde oxidase …
studies. Despite the importance of genetic polymorphisms in cytosolic aldehyde oxidase …