The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate
host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the …

Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Photoreceptor cells maintain a roughly constant length by continuously generating new
outer segments from their base while simultaneously releasing mature outer segments …

Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …