Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
DR Nässel, M Zandawala - Progress in neurobiology, 2019 - Elsevier
This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …
class of neuroactive substances, known in Drosophila and other animals to play roles in …
[HTML][HTML] JNK at the crossroad of obesity, insulin resistance, and cell stress response
G Solinas, B Becattini - Molecular metabolism, 2017 - Elsevier
Abstract Background The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress
response, with outcomes ranging from cell death to cell proliferation and survival, depending …
response, with outcomes ranging from cell death to cell proliferation and survival, depending …
[HTML][HTML] PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan
Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …
metazoans. Their deregulation is associated with age-related pathologies like chronic …
Mitochondria, oxidants, and aging
RS Balaban, S Nemoto, T Finkel - cell, 2005 - cell.com
The free radical theory of aging postulates that the production of intracellular reactive
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …
Glutathione transferases
JD Hayes, JU Flanagan… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …
Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila
Declining insect population sizes are provoking grave concern around the world as insects
play essential roles in food production and ecosystems. Environmental contamination by …
play essential roles in food production and ecosystems. Environmental contamination by …
Stress-activated cap'n'collar transcription factors in aging and human disease
GP Sykiotis, D Bohmann - Science signaling, 2010 - science.org
Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
Crosstalk between oxidative stress and SIRT1: impact on the aging process
A Salminen, K Kaarniranta, A Kauppinen - International journal of …, 2013 - mdpi.com
Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …
studies have revealed that a low-level oxidative stress can even extend the lifespan of …
The redox stress hypothesis of aging
RS Sohal, WC Orr - Free Radical Biology and Medicine, 2012 - Elsevier
The main objective of this review is to examine the role of endogenous reactive
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …
oxygen/nitrogen species (ROS) in the aging process. Until relatively recently, ROS were …
Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
Gut homeostasis is controlled by both immune and developmental mechanisms, and its
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …
disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the …