Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Childhood stroke

PB Sporns, HJ Fullerton, S Lee, H Kim, WD Lo… - Nature Reviews …, 2022 - nature.com
Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks

K Soon, M Li, R Wu, A Zhou, N Khosraviani, WD Turner… - Biomaterials, 2022 - Elsevier
Brain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood
vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one …

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations

J Ren, Y Huang, Y Ren, T Tu, B Qiu, D Ai, Z Bi, X Bai… - Brain, 2023 - academic.oup.com
Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …

Brain arteriovenous malformation in hereditary hemorrhagic telangiectasia: Recent advances in cellular and molecular mechanisms

E Drapé, T Anquetil, B Larrivée… - Frontiers in Human …, 2022 - frontiersin.org
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by vessel
dilatation, such as telangiectasia in skin and mucosa and arteriovenous malformations …

Review of treatment and therapeutic targets in brain arteriovenous malformation

P Pan, S Weinsheimer, D Cooke… - Journal of Cerebral …, 2021 - journals.sagepub.com
Brain arteriovenous malformations (bAVM) are an important cause of intracranial
hemorrhage (ICH), especially in younger patients. The pathogenesis of bAVM are largely …

FDA-approved kinase inhibitors in preclinical and clinical trials for neurological disorders

A Lui, J Vanleuven, D Perekopskiy, D Liu, D Xu… - Pharmaceuticals, 2022 - mdpi.com
Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model

HL Nguyen, LM Boon, M Vikkula - Human Molecular Genetics, 2023 - academic.oup.com
Somatic activating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations have
been reported in patients with arteriovenous malformations. By producing LSL-Kras (G12D); …

Soluble endoglin stimulates inflammatory and angiogenic responses in microglia that are associated with endothelial dysfunction

ES Park, S Kim, DC Yao, JPJ Savarraj, HA Choi… - International Journal of …, 2022 - mdpi.com
Increased soluble endoglin (sENG) has been observed in human brain arteriovenous
malformations (bAVMs). In addition, the overexpression of sENG in concurrence with …

Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

ND Nelson, F Xu, P Chandrasekaran, LA Litzky… - Modern …, 2022 - nature.com
The potential pathogenetic mechanisms underlying the varied morphology of congenital
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a …