Vascular endothelial cells: heterogeneity and targeting approaches
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
Childhood stroke
PB Sporns, HJ Fullerton, S Lee, H Kim, WD Lo… - Nature Reviews …, 2022 - nature.com
Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …
A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
K Soon, M Li, R Wu, A Zhou, N Khosraviani, WD Turner… - Biomaterials, 2022 - Elsevier
Brain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood
vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one …
vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one …
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
J Ren, Y Huang, Y Ren, T Tu, B Qiu, D Ai, Z Bi, X Bai… - Brain, 2023 - academic.oup.com
Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
Brain arteriovenous malformation in hereditary hemorrhagic telangiectasia: Recent advances in cellular and molecular mechanisms
E Drapé, T Anquetil, B Larrivée… - Frontiers in Human …, 2022 - frontiersin.org
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by vessel
dilatation, such as telangiectasia in skin and mucosa and arteriovenous malformations …
dilatation, such as telangiectasia in skin and mucosa and arteriovenous malformations …
Review of treatment and therapeutic targets in brain arteriovenous malformation
P Pan, S Weinsheimer, D Cooke… - Journal of Cerebral …, 2021 - journals.sagepub.com
Brain arteriovenous malformations (bAVM) are an important cause of intracranial
hemorrhage (ICH), especially in younger patients. The pathogenesis of bAVM are largely …
hemorrhage (ICH), especially in younger patients. The pathogenesis of bAVM are largely …
FDA-approved kinase inhibitors in preclinical and clinical trials for neurological disorders
A Lui, J Vanleuven, D Perekopskiy, D Liu, D Xu… - Pharmaceuticals, 2022 - mdpi.com
Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …
Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model
Somatic activating Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations have
been reported in patients with arteriovenous malformations. By producing LSL-Kras (G12D); …
been reported in patients with arteriovenous malformations. By producing LSL-Kras (G12D); …
Soluble endoglin stimulates inflammatory and angiogenic responses in microglia that are associated with endothelial dysfunction
Increased soluble endoglin (sENG) has been observed in human brain arteriovenous
malformations (bAVMs). In addition, the overexpression of sENG in concurrence with …
malformations (bAVMs). In addition, the overexpression of sENG in concurrence with …
Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features
The potential pathogenetic mechanisms underlying the varied morphology of congenital
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a …
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a …