Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane
to facilitate the cotranslational membrane insertion of the synthesized proteins. We report …

A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic
transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) …

Membrane protein biogenesis faces the challenge of chaperoning hydrophobic
transmembrane helices for faithful membrane insertion. The guided entry of tail-anchored …

Protein translocases, such as the bacterial SecY complex, the Sec61 complex of the
endoplasmic reticulum (ER) and the mitochondrial translocases, facilitate the transport of …

Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …

Membranes surrounding cells or organelles represent barriers to proteins and other
molecules. However, specific proteins can cross membranes by different translocation …

Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …