Gut microbiome lipid metabolism and its impact on host physiology
Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …
recognition by the immune system and their influence on numerous metabolic pathways …
Mechanisms of oxidative stress in metabolic syndrome
SK Masenga, LS Kabwe, M Chakulya… - International journal of …, 2023 - mdpi.com
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …
Extracellular miRNAs: from biomarkers to mediators of physiology and disease
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
Insulin resistance and cardiovascular disease
CE Kosmas, MD Bousvarou… - Journal of …, 2023 - journals.sagepub.com
Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …
health hazards, especially in today's Western societies. A causal-effect relationship has …
Inflammation, metaflammation and immunometabolic disorders
GS Hotamisligil - Nature, 2017 - nature.com
Proper regulation and management of energy, substrate diversity and quantity, as well as
macromolecular synthesis and breakdown processes, are fundamental to cellular and …
macromolecular synthesis and breakdown processes, are fundamental to cellular and …
Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging
S Ma, S Sun, L Geng, M Song, W Wang, Y Ye, Q Ji… - Cell, 2020 - cell.com
Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …
Skeletal muscle inflammation and insulin resistance in obesity
H Wu, CM Ballantyne - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …
[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …
Defining the underlying defect in insulin action in type 2 diabetes
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …
the past 50 years, elucidation of the insulin signalling network has provided important …
Understanding the mysterious M2 macrophage through activation markers and effector mechanisms
T Rőszer - Mediators of inflammation, 2015 - Wiley Online Library
The alternatively activated or M2 macrophages are immune cells with high phenotypic
heterogeneity and are governing functions at the interface of immunity, tissue homeostasis …
heterogeneity and are governing functions at the interface of immunity, tissue homeostasis …