The fruit fly, Drosophila melanogaster, has a long and rich history as an important model
organism for biologists. In particular, study of the fruit fly has been essential to much of our …

Duchenne muscular dystrophy is caused by mutations in the dystrophin gene and is
characterized by progressive muscle wasting. A number of Duchenne patients also present …

The original sarcoglycan (SG) complex has four subunits and comprises a subcomplex of
the dystrophin–dystrophin‐associated protein complex. Each SG gene has been shown to …

Perturbation in the Dystroglycan (Dg)–Dystrophin (Dys) complex results in muscular
dystrophies and brain abnormalities in human. Here we report that Drosophila is an …

A number of studies have been conducted recently on the model organism Drosophila to
determine the function of genes involved in human disease, including those implicated in …

Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological
processes. The ECM plays fundamental developmental and physiological roles in health …

During the last 15 years, following its identification and first detailed molecular
characterization, the dystroglycan (DG) complex has taken centre stage in biology and …

The C. elegans dystroglycan (DG) homolog DGN-1 is expressed in epithelia and neurons,
and localizes to basement membrane (BM) surfaces. Unlike vertebrate DG, DGN-1 is not …

Mutations in the human dystrophin gene cause the Duchenne and Becker muscular
dystrophies. The Dystrophin protein provides a structural link between the muscle …

Drosophila melanogaster provides a powerful platform with which researchers can dissect
complex genetic questions and biochemical pathways relevant to a vast array of human …