Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

TGF-β-induced epithelial to mesenchymal transition

J Xu, S Lamouille, R Derynck - Cell research, 2009 - nature.com
During development and in the context of different morphogenetic events, epithelial cells
undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT) …

Transcriptional regulation of EMT transcription factors in cancer

M Saitoh - Seminars in Cancer Biology, 2023 - Elsevier
The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

H Peinado, D Olmeda, A Cano - Nature reviews cancer, 2007 - nature.com
The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased …

Mechanisms of TGFβ-induced epithelial–mesenchymal transition

A Moustakas, CH Heldin - Journal of clinical medicine, 2016 - mdpi.com
Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

EMT as the ultimate survival mechanism of cancer cells

N Tiwari, A Gheldof, M Tatari, G Christofori - Seminars in cancer biology, 2012 - Elsevier
Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

Molecular requirements for epithelial–mesenchymal transition during tumor progression

MA Huber, N Kraut, H Beug - Current opinion in cell biology, 2005 - Elsevier
Epithelial–mesenchymal transitions (EMTs) occur as key steps during embryonic
morphogenesis, and are now implicated in the progression of primary tumors towards …

TGF-β and epithelial-to-mesenchymal transitions

J Zavadil, EP Böttinger - Oncogene, 2005 - nature.com
Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …

TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease

BC Willis, Z Borok - American Journal of Physiology-Lung …, 2007 - journals.physiology.org
Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial
cells undergo transition to a mesenchymal phenotype giving rise to fibroblasts and …

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

XM Meng, ACK Chung, HY Lan - Clinical science, 2013 - portlandpress.com
TGF-β (transforming growth factor-β) and BMP-7 (bone morphogenetic protein-7), two key
members in the TGF-β superfamily, play important but diverse roles in CKDs (chronic kidney …