Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …
TGF-β-induced epithelial to mesenchymal transition
J Xu, S Lamouille, R Derynck - Cell research, 2009 - nature.com
During development and in the context of different morphogenetic events, epithelial cells
undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT) …
undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT) …
Transcriptional regulation of EMT transcription factors in cancer
M Saitoh - Seminars in Cancer Biology, 2023 - Elsevier
The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased …
recently our knowledge of particular aspects of some of these processes has increased …
Mechanisms of TGFβ-induced epithelial–mesenchymal transition
A Moustakas, CH Heldin - Journal of clinical medicine, 2016 - mdpi.com
Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …
embryonic cells to generate migratory descendants that populate new sites and establish …
EMT as the ultimate survival mechanism of cancer cells
Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …
Molecular requirements for epithelial–mesenchymal transition during tumor progression
MA Huber, N Kraut, H Beug - Current opinion in cell biology, 2005 - Elsevier
Epithelial–mesenchymal transitions (EMTs) occur as key steps during embryonic
morphogenesis, and are now implicated in the progression of primary tumors towards …
morphogenesis, and are now implicated in the progression of primary tumors towards …
TGF-β and epithelial-to-mesenchymal transitions
J Zavadil, EP Böttinger - Oncogene, 2005 - nature.com
Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
BC Willis, Z Borok - American Journal of Physiology-Lung …, 2007 - journals.physiology.org
Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial
cells undergo transition to a mesenchymal phenotype giving rise to fibroblasts and …
cells undergo transition to a mesenchymal phenotype giving rise to fibroblasts and …
Role of the TGF-β/BMP-7/Smad pathways in renal diseases
TGF-β (transforming growth factor-β) and BMP-7 (bone morphogenetic protein-7), two key
members in the TGF-β superfamily, play important but diverse roles in CKDs (chronic kidney …
members in the TGF-β superfamily, play important but diverse roles in CKDs (chronic kidney …