Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Pore formation in regulated cell death

H Flores‐Romero, U Ros, AJ Garcia‐Saez - The EMBO journal, 2020 - embopress.org
The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

The role of cell‐penetrating peptides in potential anti‐cancer therapy

M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria

CA Roque-Borda, PB Da Silva, MC Rodrigues… - European Journal of …, 2022 - Elsevier
Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant
results in the fight against some diseases. Antimicrobial peptides (AMPs) are …

TisB protein is the single molecular determinant underlying multiple downstream effects of ofloxacin in Escherichia coli

J Cayron, T Oms, T Schlechtweg, S Zedek… - Science …, 2024 - science.org
Bactericidal antibiotics can cause metabolic perturbations that contribute to antibiotic-
induced lethality. The molecular mechanism underlying these downstream effects remains …

Antimicrobial mechanisms of biomaterials: from macro to nano

S Roy, S Sarkhel, D Bisht, SN Hanumantharao… - Biomaterials …, 2022 - pubs.rsc.org
Overcoming the global concern of antibiotic resistance is one of the biggest challenges
faced by scientists today, and the key to tackling this issue of emerging infectious diseases is …

Biophysical investigations elucidating the mechanisms of action of antimicrobial peptides and their synergism

A Marquette, B Bechinger - Biomolecules, 2018 - mdpi.com
Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …

The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations

C Aisenbrey, A Marquette, B Bechinger - Antimicrobial Peptides: Basics …, 2019 - Springer
Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis

K Scheinpflug, M Wenzel, O Krylova, JE Bandow… - Scientific reports, 2017 - nature.com
The synthetic cyclic hexapeptide cWFW (cyclo (RRRWFW)) has a rapid bactericidal activity
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …

[HTML][HTML] Small-angle scattering techniques for peptide and peptide hybrid nanostructures and peptide-based biomaterials

IW Hamley, V Castelletto - Advances in Colloid and Interface Science, 2023 - Elsevier
The use of small-angle scattering (SAS) in the study of self-assembly of peptides and
peptide conjugates (lipopeptides, polymer-peptide conjugates and others) is reviewed …