Spheroid culture system methods and applications for mesenchymal stem cells

NE Ryu, SH Lee, H Park - Cells, 2019 - mdpi.com
Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …

Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment

L Hu, C Yin, F Zhao, A Ali, J Ma, A Qian - International Journal of …, 2018 - mdpi.com
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

Disorders of bone remodeling

X Feng, JM McDonald - Annual Review of Pathology …, 2011 - annualreviews.org
The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications

D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …

[HTML][HTML] Bioelectric signaling in regeneration: mechanisms of ionic controls of growth and form

KA McLaughlin, M Levin - Developmental biology, 2018 - Elsevier
The ability to control pattern formation is critical for the both the embryonic development of
complex structures as well as for the regeneration/repair of damaged or missing tissues and …

Role of membrane potential in the regulation of cell proliferation and differentiation

S Sundelacruz, M Levin, DL Kaplan - Stem cell reviews and reports, 2009 - Springer
Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and
non-excitable cell types, offers enormous potential for modulation of important cell functions …

Calcium/calmodulin signaling controls osteoblast growth and differentiation

M Zayzafoon - Journal of cellular biochemistry, 2006 - Wiley Online Library
Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular
processes including fertilization, mitosis, neuronal transmission, contraction and relaxation …

Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system

D Docheva, C Popov, W Mutschler… - Journal of cellular and …, 2007 - Wiley Online Library
• Mesenchymal stem cells and their clinical relevance‐Alternative names and criteria to
define MSCs‐Tissue sources‐Some 'good'and 'bad'sides of MSCs• Integrins and their …

How does spaceflight affect the acquired immune system?

T Akiyama, K Horie, E Hinoi, M Hiraiwa, A Kato… - npj …, 2020 - nature.com
The impact of spaceflight on the immune system has been investigated extensively during
spaceflight missions and in model experiments conducted on Earth. Data suggest that the …