Methanol and ethylene glycol intoxication

JA Kruse - Critical care clinics, 2012 - criticalcare.theclinics.com
The word alcohol is commonly used to specifically refer to ethyl alcohol or ethanol. However,
in chemical terms, alcohol can refer to any hydroxyl derivative of a hydrocarbon. By …

Photorespiratory glycolate–glyoxylate metabolism

Y Dellero, M Jossier, J Schmitz… - Journal of …, 2016 - academic.oup.com
Photorespiration is one of the major carbon metabolism pathways in oxygen-producing
photosynthetic organisms. This pathway recycles 2-phosphoglycolate (2-PG), a toxic …

Oxygen activation in flavoprotein oxidases: the importance of being positive

G Gadda - Biochemistry, 2012 - ACS Publications
The oxidation of flavin hydroquinones by O2 in solution is slow, with second-order rate
constants of∼ 250 M–1 s–1. This is due to the obligatory, single-electron transfer that …

[HTML][HTML] 2-Hydroxy acids in plant metabolism

VG Maurino, MKM Engqvist - The Arabidopsis book/American …, 2015 - ncbi.nlm.nih.gov
Abstract Glycolate, malate, lactate, and 2-hydroxyglutarate are important 2-hydroxy acids
(2HA) in plant metabolism. Most of them can be found as D-and L-stereoisomers. These …

[HTML][HTML] Engineering approaches for O2-dependent Enzymes

A Al-Shameri, L Schmermund, V Sieber - Current Opinion in Green and …, 2023 - Elsevier
O 2-dependent biocatalysts are among the most studied and used biocatalysts on the lab
scale. Their diversity and functional versatility make them very attractive for the sustainable …

Computational analysis of hydride and proton transfer steps in l-lactate oxidase based on QM and QM–MM methods

I Yildiz - Journal of Molecular Structure, 2024 - Elsevier
L-Lactate oxidase (LOX) is a member of α‑hydroxy acid-oxidizing enzymes, and it catalyzes
oxidation of l-lactate into pyruvate using flavin mononucleotide (FMN) as cofactor. Based on …

Small molecule-based enzyme inhibitors in the treatment of primary hyperoxalurias

MD Moya-Garzon, JA Gomez-Vidal… - Journal of Personalized …, 2021 - mdpi.com
Primary hyperoxalurias (PHs) are a group of inherited alterations of the hepatic glyoxylate
metabolism. PHs classification based on gene mutations parallel a variety of enzymatic …

Characterization of OsPIN2 Mutants Reveal Novel Roles for Reactive Oxygen Species in Modulating Not Only Root Gravitropism but Also Hypoxia Tolerance in Rice …

B Hao, R Zhang, C Zhang, N Wen, Y Xia, Y Zhao, Q Li… - Plants, 2024 - mdpi.com
Tolerance to submergence-induced hypoxia is an important agronomic trait especially for
crops in lowland and flooding-affected areas. Although rice (Oryza sativa) is considered a …

Experimental evidence for a hydride transfer mechanism in plant glycolate oxidase catalysis

Y Dellero, C Mauve, E Boex-Fontvieille, V Flesch… - Journal of Biological …, 2015 - ASBMB
In plants, glycolate oxidase is involved in the photorespiratory cycle, one of the major fluxes
at the global scale. To clarify both the nature of the mechanism and possible differences in …

An active site mutation induces oxygen reactivity in D-arginine dehydrogenase: A case of superoxide diverting protons

JA Quaye, KE Wood, C Snelgrove, D Ouedraogo… - Journal of Biological …, 2024 - ASBMB
Enzymes are potent catalysts that increase biochemical reaction rates by several orders of
magnitude. Flavoproteins are a class of enzymes whose classification relies on their ability …