[HTML][HTML] Systematic review on estimated rates of nephrotoxicity and neurotoxicity in patients treated with polymyxins

F Wagenlehner, E Lucenteforte, F Pea… - Clinical Microbiology …, 2021 - Elsevier
Background Nephrotoxicity and neurotoxicity are commonly associated with polymyxin
treatment; however, the emergence of multidrug-resistant Gram-negative bacteria with …

Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli

M Zeng, J Xia, Z Zong, Y Shi, Y Ni, F Hu, Y Chen… - Journal of Microbiology …, 2023 - Elsevier
The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

International consensus guidelines for the optimal use of the polymyxins: endorsed by the American college of clinical pharmacy (ACCP), European society of clinical …

BT Tsuji, JM Pogue, AP Zavascki… - … : The Journal of …, 2019 - Wiley Online Library
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Efficacy and toxicity of aerosolised colistin in ventilator-associated pneumonia: a prospective, randomised trial

S Abdellatif, A Trifi, F Daly, K Mahjoub, R Nasri… - Annals of intensive …, 2016 - Springer
Background Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant
(MDR) gram-negative bacilli (GNB) mainly Acinetobacter baumannii, Pseudomonas …

The safety of polymyxin antibiotics

T Kelesidis, ME Falagas - Expert opinion on drug safety, 2015 - Taylor & Francis
Introduction: The emergence of multidrug-resistant gram-negative bacteria has led to the
increasing use of polymyxins. Nephrotoxicity and, to a lesser degree, neurotoxicity occur …

Nephrotoxicity prevalence in patients treated with polymyxins: a systematic review with meta-analysis of observational studies

AF Oliota, ST Penteado, FS Tonin… - … and infectious disease, 2019 - Elsevier
Colistin and polymyxin B are increasingly reintroduced in clinical practice due to the
absence of effective antibiotics for the treatment of emerging infections caused by gram …

[HTML][HTML] Appropriate use of colistin in neonates, infants and children: Interim guidance

V Chibabhai, A Bekker, M Black… - … African Journal of …, 2023 - ncbi.nlm.nih.gov
This document provides interim recommendations for appropriate colistin use (polymyxin E)
to treat bacterial infections in neonates, infants, and children. Colistin, a polymyxin antibiotic …

Pharmacokinetics of colistin following a single dose of intravenous colistimethate sodium in critically ill neonates

N Nakwan, S Usaha, K Chokephaibulkit… - The Pediatric …, 2016 - journals.lww.com
In this study, we sought to evaluate the pharmacokinetics of colistin after intravenous
administration of colistimethate sodium (CMS) in the critically ill neonates with Gram …

Efficacy and safety of intravenous combined with aerosolised polymyxin versus intravenous polymyxin alone in the treatment of multidrug-resistant gram-negative …

D Lu, W Mao - Heliyon, 2023 - cell.com
Background Previous studies have questioned the efficacy and safety of intravenous
combined with aerosolised (IV+ AS) polymyxin versus intravenous (IV) polymyxin alone in …

Management of pneumonia in the pediatric critical care unit: an area for antimicrobial stewardship

A M. Dassner, D P. Nicolau… - Current pediatric …, 2017 - benthamdirect.com
Background: Pediatric pneumonia is one of the most common causes of childhood infection
requiring hospitalization and is a substantial driver of antimicrobial use among hospitalized …