The cell biology of synapse formation
TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …
information during transfer. The diverse computational properties of synapses are shaped by …
Synaptic specificity, recognition molecules, and assembly of neural circuits
JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …
that underlie brain function. By comparison to earlier steps in neural development, progress …
The tethered peptide activation mechanism of adhesion GPCRs
X Barros-Álvarez, RM Nwokonko, A Vizurraga… - Nature, 2022 - nature.com
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-
proteolysing extracellular regions that are involved in cell–cell and cell–extracellular matrix …
proteolysing extracellular regions that are involved in cell–cell and cell–extracellular matrix …
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
X Qu, N Qiu, M Wang, B Zhang, J Du, Z Zhong, W Xu… - Nature, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological
processes such as immune responses, organ development, cellular communication …
processes such as immune responses, organ development, cellular communication …
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited
knowledge of their ligand regulation or structure is available,–. Here we report that …
knowledge of their ligand regulation or structure is available,–. Here we report that …
Alternative splicing of latrophilin-3 controls synapse formation
The assembly and specification of synapses in the brain is incompletely understood,–.
Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G …
Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G …
Cortical wiring by synapse type–specific control of local protein synthesis
Neurons use local protein synthesis to support their morphological complexity, which
requires independent control across multiple subcellular compartments up to the level of …
requires independent control across multiple subcellular compartments up to the level of …
Mechanisms of adhesion G protein–coupled receptor activation
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …
Class B GPCRs that control a wide array of physiological processes and are implicated in …
Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
Genes encoding cell-surface proteins control nervous system development and are
implicated in neurological disorders. These genes produce alternative mRNA isoforms …
implicated in neurological disorders. These genes produce alternative mRNA isoforms …
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
P Kjer-Hansen, RJ Weatheritt - Nature Structural & Molecular Biology, 2023 - nature.com
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …