The cell biology of synapse formation

TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Synaptic specificity, recognition molecules, and assembly of neural circuits

JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

The tethered peptide activation mechanism of adhesion GPCRs

X Barros-Álvarez, RM Nwokonko, A Vizurraga… - Nature, 2022 - nature.com
Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-
proteolysing extracellular regions that are involved in cell–cell and cell–extracellular matrix …

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

X Qu, N Qiu, M Wang, B Zhang, J Du, Z Zhong, W Xu… - Nature, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological
processes such as immune responses, organ development, cellular communication …

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

YQ Ping, C Mao, P Xiao, RJ Zhao, Y Jiang, Z Yang… - Nature, 2021 - nature.com
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited
knowledge of their ligand regulation or structure is available,–. Here we report that …

Alternative splicing of latrophilin-3 controls synapse formation

S Wang, C DeLeon, W Sun, SR Quake, BL Roth… - Nature, 2024 - nature.com
The assembly and specification of synapses in the brain is incompletely understood,–.
Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G …

Cortical wiring by synapse type–specific control of local protein synthesis

C Bernard, D Exposito-Alonso, M Selten, S Sanalidou… - Science, 2022 - science.org
Neurons use local protein synthesis to support their morphological complexity, which
requires independent control across multiple subcellular compartments up to the level of …

Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - ASBMB
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease

TA Ray, K Cochran, C Kozlowski, J Wang… - Nature …, 2020 - nature.com
Genes encoding cell-surface proteins control nervous system development and are
implicated in neurological disorders. These genes produce alternative mRNA isoforms …

The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts

P Kjer-Hansen, RJ Weatheritt - Nature Structural & Molecular Biology, 2023 - nature.com
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …