Gene regulation in time and space during X-chromosome inactivation
A Loda, S Collombet, E Heard - Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
[HTML][HTML] Progress toward understanding chromosome silencing by Xist RNA
The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
The implication of early chromatin changes in X chromosome inactivation
During development, the precise relationships between transcription and chromatin
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm …
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm …
The second decade of 3C technologies: detailed insights into nuclear organization
A Denker, W De Laat - Genes & development, 2016 - genesdev.cshlp.org
The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …
and thereby for cellular fate at large is now widely accepted. Our understanding of the …
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape
Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
[HTML][HTML] SMCHD1 merges chromosome compartments and assists formation of super-structures on the inactive X
Mammalian chromosomes are partitioned into A/B compartments and topologically
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …
Escape artists of the X chromosome
BP Balaton, CJ Brown - Trends in Genetics, 2016 - cell.com
Inactivation of one X chromosome in mammalian females achieves dosage compensation
between XX females and XY males; however, over 15% of human X-linked genes continue …
between XX females and XY males; however, over 15% of human X-linked genes continue …
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure
M Borensztein, L Syx, K Ancelin… - Nature structural & …, 2017 - nature.com
The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse
preimplantation female embryos and mediates transcriptional silencing of that chromosome …
preimplantation female embryos and mediates transcriptional silencing of that chromosome …
Escape from X-chromosome inactivation: an evolutionary perspective
BJ Posynick, CJ Brown - Frontiers in cell and developmental biology, 2019 - frontiersin.org
Sex chromosomes originate as a pair of homologus autosomes that then follow a general
pattern of divergence. This is evident in mammalian sex chromosomes, which have …
pattern of divergence. This is evident in mammalian sex chromosomes, which have …
The X chromosome in space
T Jégu, E Aeby, JT Lee - Nature Reviews Genetics, 2017 - nature.com
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …