Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Functional circuits and signal processing in the enteric nervous system

C Fung, P Vanden Berghe - Cellular and Molecular Life Sciences, 2020 - Springer
The enteric nervous system (ENS) is an extensive network comprising millions of neurons
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …

Novel functional roles for enteric glia in the gastrointestinal tract

BD Gulbransen, KA Sharkey - Nature reviews Gastroenterology & …, 2012 - nature.com
Enteric glia are a unique class of peripheral glial cells within the gastrointestinal tract. Major
populations of enteric glia are found in enteric ganglia in the myenteric and submucosal …

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

BD Gulbransen, M Bashashati, SA Hirota, X Gui… - Nature medicine, 2012 - nature.com
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions
associated with long-term gut dysfunction resulting from alterations to the enteric nervous …

Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury

C Laranjeira, K Sandgren, N Kessaris… - The Journal of …, 2011 - Am Soc Clin Investig
The enteric nervous system (ENS) in mammals forms from neural crest cells during
embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS …

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system

W Boesmans, R Lasrado, P Vanden Berghe, V Pachnis - Glia, 2015 - Wiley Online Library
Enteric glial cells are vital for the autonomic control of gastrointestinal homeostasis by the
enteric nervous system. Several different functions have been assigned to enteric glial cells …

Emerging roles for enteric glia in gastrointestinal disorders

KA Sharkey - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Enteric glia are important components of the enteric nervous system (ENS) and also form an
extensive network in the mucosa of the gastrointestinal (GI) tract. Initially regarded as …

Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice

JL McClain, V Grubišić, D Fried, RA Gomez-Suarez… - Gastroenterology, 2014 - Elsevier
Background & Aims In the enteric nervous system, neurotransmitters initiate changes in
calcium (Ca 2+ responses) in glia, but it is not clear how this process affects intestinal …

[HTML][HTML] Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide

IAM Brown, JL McClain, RE Watson, BA Patel… - Cellular and molecular …, 2016 - Elsevier
Background & Aims The concept of enteric glia as regulators of intestinal homeostasis is
slowly gaining acceptance as a central concept in neurogastroenterology. Yet how glia …

Circuit-specific enteric glia regulate intestinal motor neurocircuits

MM Ahmadzai, L Seguella… - Proceedings of the …, 2021 - National Acad Sciences
Glia in the central nervous system exert precise spatial and temporal regulation over neural
circuitry on a synapse-specific basis, but it is unclear if peripheral glia share this exquisite …