Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Organ crosstalk and dysfunction in sepsis

A Borges, L Bento - Annals of Intensive Care, 2024 - Springer
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Sepsis-associated organ dysfunction involves multiple inflammatory mechanisms and …

Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation

T Du, L Xiang, J Zhang, C Yang, W Zhao, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction The study aimed to explore the association of serum 25 (OH) D3 and hepatic
steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the …

Isolation, purification, and physicochemical characterization of Polygonatum polysaccharide and its protective effect against CCl4-induced liver injury via Nrf2 and NF …

G Yuan, Y Wang, H Niu, Y Ma, J Song - International Journal of Biological …, 2024 - Elsevier
This study aimed to provide scientific evidence that Polygonatum polysaccharide can be
developed as a dietary supplement and medication for treating liver injuries. A water-soluble …

Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish

Y Liu, D Zhu, J Liu, X Sun, F Gao, H Duan… - Frontiers in …, 2023 - frontiersin.org
Introduction Obesity is a health issue worldwide. This study aimed to evaluate the beneficial
effects of Pediococcus pentococcus PR-1 on the modulating of gut microbiota, inflammation …

Ameliorating the effect and mechanism of chitosan oligosaccharide on nonalcoholic fatty liver disease in mice

J Zhang, J Feng, Y Bai, Q Che, H Cao, J Guo, Z Su - Food & Function, 2023 - pubs.rsc.org
Previous studies have found that chitosan oligosaccharide (COST) can alleviate the clinical
symptoms in non-alcoholic fatty liver disease (NAFLD) patients. We intend to intervene with …

Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis

J Li, Z Ma, Z Yang, M Yang, C Li, M Li, X Li… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Non-alcoholic steatohepatitis (NASH) has emerged as a
major cause of cirrhosis and hepatocellular carcinoma, posing a significant threat to public …

Antidiabetic Effect of Fermented Mesembryanthemum crystallinum L. in db/db Mice Involves Regulation of PI3K-Akt Pathway

HL Kim, Y Jung, HI Kim, NY Sung, MJ Kim… - Current Issues in …, 2023 - mdpi.com
Type 2 diabetes (T2D) is a serious health issue with increasing incidences worldwide.
However, current medications have limitations due to side effects such as decreased …

RNA-Seq reveals pathways responsible for meat quality characteristic differences between two Yunnan indigenous chicken breeds and commercial broilers

Y Liu, X Zhang, K Wang, Q Li, S Yan, H Shi, L Liu… - Foods, 2024 - mdpi.com
Poultry is a source of meat that is in great demand in the world. The quality of meat is an
imperative point for shoppers. To explore the genes controlling meat quality characteristics …

The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats Fed with High-Carbohydrate High-Fat Diet

KN Hashim, KY Chin, F Ahmad - Molecules, 2023 - mdpi.com
Metabolic syndrome (MetS) is composed of central obesity, hyperglycemia, dyslipidemia
and hypertension that increase an individual's tendency to develop type 2 diabetes mellitus …