Mood and anxiety disorders are prevalent conditions affecting one out of four people during
lifetime. The development of high validity animal models to study these disorders has been a …

Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Exposure to stress is highly correlated with the emergence of mood-related illnesses.
Because major depressive disorder often emerges in adolescence, we assessed the effects …

Background Stress is a prevailing risk factor for mood-related illnesses, wherein women
represent the majority of those affected by major depression. Despite the growing literature …

Social stress, including bullying during adolescence, is a risk factor for common
psychopathologies such as depression. To investigate the neural mechanisms associated …

Background Drugs prescribed for psychiatric disorders in adolescence should be studied
very extensively since they can affect developing and thus highly plastic brain differently …

Depression is a complex and highly heterogeneous disorder which diagnosis is based on
an exceedingly variable set of clinical symptoms. Current treatments focus almost …

The chronic social defeat stress model has been instrumental in shaping our understanding
of neurobiology relevant to affect-related illnesses, including major depressive disorder …

Lifelong homeostatic setpoints for mood-related behaviors emerge during adolescence.
Serotonin (5-HT) plays an important role in refining the formation of brain circuits during …

Emerging evidence indicates that treatment context profoundly affects
psychopharmacological interventions. We review the evidence for the interaction between …