The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …

The discovery of the cannabinoid receptors CB1 and CB2 in 19881, 2 and 1990, 3
respectively, and of the endogenous cannabinoid ligands (endocannabinoids) …

The endocannabinoid signalling system includes:(1) at least two G-protein-coupled
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …

Endocannabinoids were defined in 1995 as endogenous agonists of cannabinoid receptors,
ie of the G protein-coupled receptors for cannabis's psychoactive principle, Δ 9 …

Endovanilloids are defined as endogenous ligands and activators of transient receptor
potential (TRP) vanilloid type 1 (TRPV1) channels. The first endovanilloid to be identified …

As far as can be ascertained from archeological sources, preparations of the hemp
Cannabis sativa L. were widely used by humans for either therapeutic or ritual purposes in …

A rather complex and pleiotropic endogenous signalling system was discovered in the late
1990s, starting from studies on the mechanism of action of Δ9-tetrahydrocannabinol, the …

The gut microbiota is a unique ecosystem of microorganisms interacting with the host
through several biochemical mechanisms. The endocannabinoidome (eCBome), a complex …

The molecular mechanism of action of Δ 9-tetrahydrocannabinol (THC), the psychotropic
constituent of Cannabis, has been a puzzle during the three decades separating its …