Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Various whole cell-based biosensors have been reported in the literature for the last 20
years and these reports have shown great potential for their use in the areas of pollution …

Basal cell carcinoma (BCC) of the skin is the most common malignant neoplasm in humans.
BCC is primarily driven by the Sonic Hedgehog (Hh) pathway. However, its phenotypic …

How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …

Sequencing complete tumor genomes and exomes has sparked the cancer field's interest in
mutation signatures for identifying the tumor's carcinogen. This review and meta‐analysis …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically
linked to skin cancer, a spectrum of diseases of rising incidence in many human …

The risk of onset of cancer is influenced by poorly controlled chronic inflammatory
processes. Inflammatory diseases related to cancer development include inflammatory …

The survey focuses on recent aspects of photochemical reactions to cellular DNA that are
implicated through the predominant formation of mostly bipyrimidine photoproducts in …

Solar UVB is carcinogenic. Nucleotide excision repair (NER) counteracts the carcinogenicity
of UVB by excising potentially mutagenic UVB-induced DNA lesions. Despite this capacity …