The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

During embryonic development, digits gradually emerge in a periodic pattern. Although
genetic evidence indicates that digit formation results from a self-organizing process, the …

Localized sources of morphogens, called signalling centres, play a fundamental role in
coordinating tissue growth and cell fate specification during organogenesis. However, how …

Although rigidity and jamming transitions have been widely studied in physics and material
science, their importance in a number of biological processes, including embryo …

Biological self-assembly is crucial in the processes of development, tissue regeneration, and
maturation of bioprinted tissue-engineered constructions. The cell aggregates—spheroids …

Increasing evidence shows that mechanical stresses are critical in regulating cell functions,
fate, and diseases. However, no methods exist that can quantify isotropic compressive …

The bioorthogonal nature of perfluorocarbons provides a unique platform for introducing
dynamic nano-and microdroplets into cells and organisms. To monitor the localization and …

Mechanics is known to play a fundamental role in many cellular and developmental
processes. Beyond active forces and material properties, osmotic pressure is believed to …