Microdosing and drug development: past, present and future
Introduction: Microdosing is an approach to early drug development where exploratory
pharmacokinetic data are acquired in humans using inherently safe sub-pharmacologic …
pharmacokinetic data are acquired in humans using inherently safe sub-pharmacologic …
DNA adducts: mass spectrometry methods and future prospects
Detection of DNA adducts is widely used for the monitoring of exposure to genotoxic
carcinogens. Knowledge of the nature and amounts of DNA adducts formed in vivo also …
carcinogens. Knowledge of the nature and amounts of DNA adducts formed in vivo also …
Investigation of the role of quercetin as a heat shock protein inhibitor on apoptosis in human breast cancer cells
High expression of heat shock proteins (Hsp) in breast cancer has been closely associated
with tumor cell proliferation and thus a poor clinical outcome. Quercetin, a good Hsp inhibitor …
with tumor cell proliferation and thus a poor clinical outcome. Quercetin, a good Hsp inhibitor …
Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage
MW Himmelstein, PJ Boogaard, J Cadet… - Critical reviews in …, 2009 - Taylor & Francis
The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse
consequences for cellular and whole organism function. Available methods for identification …
consequences for cellular and whole organism function. Available methods for identification …
[图书][B] Using mass spectrometry for drug metabolism studies
WA Korfmacher - 2009 - taylorfrancis.com
The first edition of this now classic work helped to establish mass spectrometry as the
premier tool for drug metabolism studies. Completely rewritten from start to finish, Using …
premier tool for drug metabolism studies. Completely rewritten from start to finish, Using …
Montmorillonite/poly-(ε-caprolactone) composites as versatile layered material: Reservoirs for anticancer drug and controlled release property
BD Kevadiya, RP Thumbar, MM Rajput… - European Journal of …, 2012 - Elsevier
This work evaluates intercalation of tamoxifen (Tmx) in interlayer gallery of Na+-MMT
(Montmorillonite, MMT)(Tmx–MMT), which is further compounded with poly-(ε …
(Montmorillonite, MMT)(Tmx–MMT), which is further compounded with poly-(ε …
Toxicophores: investigations in drug safety
DP Williams - Toxicology, 2006 - Elsevier
Adverse drug reactions, such as hepatotoxicity, blood dyscrasias and hypersensitivity are a
major obstacle for the use and the development of new medicines. Many forms of organ …
major obstacle for the use and the development of new medicines. Many forms of organ …
Development of uterine sarcoma after tamoxifen treatment for breast cancer: report of four cases
Y Yildirim, MM Inal, M Sanci, YK Yildirim… - International Journal of …, 2005 - ijgc.bmj.com
Tamoxifen (TAM) is widely used in the treatment of breast cancer, and its paradoxical effects
on female genital system are well known. During the past 10 years, many descriptions of …
on female genital system are well known. During the past 10 years, many descriptions of …
Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties
JW van der Laan, P Kasper, B Silva Lima… - Critical Reviews in …, 2016 - Taylor & Francis
Predicting the outcome of life-time carcinogenicity studies in rats based on chronic (6-month)
toxicity studies in this species is possible in some instances. This should reduce the number …
toxicity studies in this species is possible in some instances. This should reduce the number …
The DNA-damaging potential of tamoxifen in breast cancer and normal cells
K Wozniak, A Kolacinska, M Blasinska-Morawiec… - Archives of …, 2007 - Springer
Tamoxifen (TAM) is a non-steroidal anti-estrogen used widely in the treatment and
chemoprevention of breast cancer. TAM treatment can lead to DNA damage, but the …
chemoprevention of breast cancer. TAM treatment can lead to DNA damage, but the …