Systems biology brings new dimensions for structure-based drug design
In this Perspective, we focus on new, systems-centric views of structure-based drug design
(SBDD) that we believe will impact future drug discovery research and development. We will …
(SBDD) that we believe will impact future drug discovery research and development. We will …
Current status of mathematical modeling of cancer–from the viewpoint of cancer hallmarks
Cancer phenotypes, referred to as hallmarks of cancer, are acquired by dysregulation of
biochemical networks, in addition to genetic and epigenetic alterations. For the last decade …
biochemical networks, in addition to genetic and epigenetic alterations. For the last decade …
Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Mathematical models of biochemical reaction networks are an important and emerging tool
for the study of cell signaling networks involved in disease processes. One promising …
for the study of cell signaling networks involved in disease processes. One promising …
Cooperation between noncanonical Ras network mutations
Cancer develops after the acquisition of a collection of mutations that together create the
cancer phenotype. How collections of mutations work together within a cell and whether …
cancer phenotype. How collections of mutations work together within a cell and whether …
Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective
T Sun, J Cui - Progress in biophysics and molecular biology, 2015 - Elsevier
Cells are constantly challenged by intrinsic and extrinsic signals. DNA damage denotes a
serious threat to cellular survival due to its extensive destroy to genomic integrity …
serious threat to cellular survival due to its extensive destroy to genomic integrity …
Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis
L Zhao, T Sun, J Pei, Q Ouyang - Proceedings of the …, 2015 - National Acad Sciences
It has been a consensus in cancer research that cancer is a disease caused primarily by
genomic alterations, especially somatic mutations. However, the mechanism of mutation …
genomic alterations, especially somatic mutations. However, the mechanism of mutation …
[HTML][HTML] Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling
Synonymous mutations, which do not alter the encoded amino acid, have been routinely
assumed to be 'neutral'and would have no effect on phenotype or fitness. Yet increasing …
assumed to be 'neutral'and would have no effect on phenotype or fitness. Yet increasing …
Deciphering p53 dynamics and cell fate in DNA damage response using mathematical modeling
N Yang, T Sun, P Shen - Genome Instability & Disease, 2020 - Springer
The tumor suppressor p53 is activated in response to cellular stresses. The transcription
factor p53 can activate the expression of numerous genes leading to cell cycle arrest …
factor p53 can activate the expression of numerous genes leading to cell cycle arrest …
Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants
EC Stites - bioRxiv, 2014 - biorxiv.org
Emerging data suggest different activating Ras mutants may have different biological
behaviors. The most striking example may be in colon cancer, where activating KRAS …
behaviors. The most striking example may be in colon cancer, where activating KRAS …
Revealing determinants of two‐phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model
G Demirkıran, G Kalaycı Demir… - IET Systems …, 2018 - Wiley Online Library
This study proposes a two‐dimensional (2D) oscillator model of p53 network, which is
derived via reducing the multidimensional two‐phase dynamics model into a model of ataxia …
derived via reducing the multidimensional two‐phase dynamics model into a model of ataxia …