The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Pseudomonas aeruginosa causes severe and persistent infections in immune compromised
individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa …

Insect guts present distinctive environments for microbial colonization, and bacteria in the
gut potentially provide many beneficial services to their hosts. Insects display a wide range …

Most Caenorhabditis elegans studies have used laboratory Escherichia coli as diet and
microbial environment. Here we characterize bacteria of C. elegans' natural habitats of …

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or
collisions. Recent work demonstrates that RSR also plays a role in innate immunity by …

Metazoans identify and eliminate bacterial pathogens in microbe-rich environments such as
the intestinal lumen; however, the mechanisms are unclear. Host cells could potentially use …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Oligogalacturonides (OGs) are fragments of pectin that activate plant innate immunity by
functioning as damage-associated molecular patterns (DAMPs). We set out to test the …

Distinguishing infectious pathogens from harmless microorganisms is essential for animal
health. The mechanisms used to identify infectious microbes are not fully understood …

In the arms race of bacterial pathogenesis, bacteria produce an array of toxins and virulence
factors that disrupt core host processes. Hosts mitigate the ensuing damage by responding …