Current developments in diagnostic assays for laboratory confirmation and investigation of botulism

DA Centurioni, CT Egan, MJ Perry - Journal of Clinical …, 2022 - Am Soc Microbiol
Detection of botulinum neurotoxin or isolation of the toxin-producing organism is required for
the laboratory confirmation of botulism in clinical specimens. In an effort to reduce animal …

Variations in the botulinum neurotoxin binding domain and the potential for novel therapeutics

JR Davies, SM Liu, KR Acharya - Toxins, 2018 - mdpi.com
Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes
BoNT/A to/G). Each serotype can also be further divided into subtypes based on differences …

Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound …

J Brunt, AHM van Vliet, AT Carter, SC Stringer, C Amar… - Toxins, 2020 - mdpi.com
Clostridium botulinum Group I and Clostridium sporogenes are closely related bacteria
responsible for foodborne, infant and wound botulism. A comparative genomic study with …

Pan-Genomic Analysis of Clostridium botulinum Group II (Non-Proteolytic C. botulinum) Associated with Foodborne Botulism and Isolated from the Environment

J Brunt, AHM van Vliet, SC Stringer, AT Carter… - Toxins, 2020 - mdpi.com
The neurotoxin formed by Clostridium botulinum Group II is a major cause of foodborne
botulism, a deadly intoxication. This study aims to understand the genetic diversity and …

Rapid Detection of Clostridium botulinum in Food Using Loop-Mediated Isothermal Amplification (LAMP)

Y Chen, H Li, L Yang, L Wang, R Sun… - International Journal of …, 2021 - mdpi.com
Botulinum neurotoxins are considered as one of the most potent toxins and are produced by
Clostridium botulinum. It is crucial to have a rapid and sensitive method to detect the …

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology

L von Berg, D Stern, D Pauly, S Mahrhold… - Scientific Reports, 2019 - nature.com
Botulinum neurotoxins (BoNTs) are the most potent toxins known and cause the life
threatening disease botulism. Sensitive and broad detection is extremely challenging due to …

The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental …

TJ Smith, CHD Williamson, KK Hill… - Frontiers in …, 2021 - frontiersin.org
Of the seven currently known botulinum neurotoxin-producing species of Clostridium, C.
parabotulinum, or C. botulinum Group I, is the species associated with the majority of human …

[HTML][HTML] Health Hazard Associated with the Presence of Clostridium Bacteria in Food Products

A Bilska, K Wochna, M Habiera, K Serwańska-Leja - Foods, 2024 - mdpi.com
Clostridium bacteria were already known to Hippocrates many years before Christ. The
name of the Clostridium species is owed to the Polish microbiologist, Adam Prażmowski. It is …

Genomic characterization of newly completed genomes of Botulinum neurotoxin-producing species from Argentina, Australia, and Africa

TJ Smith, G Xie, CHD Williamson, KK Hill… - Genome Biology and …, 2020 - academic.oup.com
Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as
well as in their overall genomic composition. They are globally distributed, with prevalent …

Clostridium neonatale sp. nov. linked to necrotizing enterocolitis in neonates and a clarification of species assignable to the genus Clostridium (Prazmowski 1880) …

K Bernard, T Burdz, D Wiebe… - … of Systematic and …, 2018 - microbiologyresearch.org
A description of an outbreak of necrotizing enterocolitis among neonates, linked to the
putative novel species Clostridium neonatale and assignable to the genus Clostridium, was …