The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Current information indicates that glial cells participate in all the normal and pathological
processes of the central nervous system. Although much less is known about satellite glial …

Peripheral sensory neurons regenerate their axon after nerve injury to enable functional
recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Peripheral axons of dorsal root ganglion (DRG) neurons, but not their central axons in the
dorsal columns, regenerate after injury. However, if the neurons are conditioned by a …

Following peripheral-nerve lesions there are well-documented events that affect the
contralateral nonlesioned structures. These contralateral effects are qualitatively similar to …

Recent research has shown that peripheral mechanisms of pain are much more complex
than previously thought, and they differ for acutely injured normal tissues compared with …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA,
TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury …

The distribution of major histocompatibility complex class II (MHC II)-positive non-neuronal
cells and T-lymphocytes was examined immunohistochemically in dorsal root ganglia …