Cytoplasmic and mitochondrial NADPH-coupled redox systems in the regulation of aging
PC Bradshaw - Nutrients, 2019 - mdpi.com
The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …
against redox stress by providing reducing equivalents to antioxidants such as glutathione …
Circadian and sleep metabolomics across species
Under normal circadian function, metabolic control is temporally coordinated across tissues
and behaviors with a 24-h period. However, circadian disruption results in negative …
and behaviors with a 24-h period. However, circadian disruption results in negative …
Circadian rhythms in the absence of the clock gene Bmal1
Circadian (~ 24 hour) clocks have a fundamental role in regulating daily physiology. The
transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 …
transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 …
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth
Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with
pronounced epithelial and mesenchymal cancer cell populations. However, the cellular …
pronounced epithelial and mesenchymal cancer cell populations. However, the cellular …
Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells
Circadian clocks coordinate mammalian behavior and physiology enabling organisms to
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …
Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus
Biological rhythms are a fundamental property of life. The deep ocean covers 66% of our
planet surface and is one of the largest biomes. The deep sea has long been considered as …
planet surface and is one of the largest biomes. The deep sea has long been considered as …
12-h clock regulation of genetic information flow by XBP1s
Our group recently characterized a cell-autonomous mammalian 12-h clock independent
from the circadian clock, but its function and mechanism of regulation remain poorly …
from the circadian clock, but its function and mechanism of regulation remain poorly …
A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in …
Background Circadian rhythms broadly impact human health by regulating our daily
physiological and metabolic processes. The circadian clocks substantially regulate our …
physiological and metabolic processes. The circadian clocks substantially regulate our …
Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2
R Aviram, V Dandavate, G Manella, M Golik… - PLoS biology, 2021 - journals.plos.org
Rhythmicity of biological processes can be elicited either in response to environmental
cycles or driven by endogenous oscillators. In mammals, the circadian clock drives about 24 …
cycles or driven by endogenous oscillators. In mammals, the circadian clock drives about 24 …
A circular RNA-gawky-chromatin regulatory axis modulates stress-induced transcription
In response to heavy metal stress, the RNA-binding protein (RBP) gawky translocates into
the nucleus and acts as a chromatin-interacting factor to activate the transcription of many …
the nucleus and acts as a chromatin-interacting factor to activate the transcription of many …