Over the last several decades, the cardiac intensive care unit (CICU) has seen an increase
in the complexity of the patient population and etiologies requiring CICU admission …

Objective There are no population-based data on the relative importance of specific causes
of hypercapnic respiratory failure (HRF). We sought to quantify the associations between …

Background: Mineralocorticoid receptor (MR) antagonists decrease heart failure (HF)
hospitalization and mortality, but the mechanisms are unknown. Preclinical studies reveal …

Objective: We aimed to investigate how acute and long-term effects of atrial arrhythmias
affect the desaturation severity and characteristics determined from the oxygen saturation …

Background Patients with heart failure with preserved ejection fraction (HFpEF) exhibit many
cardiopulmonary abnormalities that could result in V˙/Q˙ mismatch, manifesting as an …

Background Emerging evidence suggests that DNA methylation can be affected by physical
activities and is associated with cardiac fibrosis. This translational research examined the …

The mechanical work of breathing (Wb) is an insightful tool used to assess respiratory
mechanics during exercise. There are several different methods used to calculate the Wb …

Purpose The aim of this systematic review was to evaluate the quality of methods used to
measure the Wb during exercise in the available literature. Methods We conducted an …

In recent decade, wearable digital devices have shown potentials for the discovery of novel
biomarkers of humans' physiology and behavior. Heart rate (HR) and respiration rate (RR) …

Little is known on the effects of respiratory patterns on baroreflex function in heart failure
(HF). Patients with HF (n= 30, age 61.6±10 years, mean±SD) and healthy controls (CNT, n …