The common message of constraint-based optimization approaches: overflow metabolism is caused by two growth-limiting constraints
Living cells can express different metabolic pathways that support growth. The criteria that
determine which pathways are selected in which environment remain unclear. One recurrent …
determine which pathways are selected in which environment remain unclear. One recurrent …
Elementary Growth Modes provide a molecular description of cellular self-fabrication
DH de Groot, J Hulshof, B Teusink… - PLoS computational …, 2020 - journals.plos.org
In this paper we try to describe all possible molecular states (phenotypes) for a cell that
fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of all …
fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of all …