[HTML][HTML] Changing epidemiology, global trends and implications for outcomes of NAFLD

VWS Wong, M Ekstedt, GLH Wong, H Hagström - Journal of hepatology, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver
disease globally and is currently estimated to affect 38% of the global population. Only a …

[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities

X Zhang, S Ha, HCH Lau, J Yu - Seminars in cancer biology, 2023 - Elsevier
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …

[HTML][HTML] Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label …

O Verrastro, S Panunzi, L Castagneto-Gissey… - The Lancet, 2023 - thelancet.com
Background Observational studies suggest that bariatric–metabolic surgery might greatly
improve non-alcoholic steatohepatitis (NASH). However, the efficacy of surgery on NASH …

[HTML][HTML] Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019

B Chong, J Jayabaskaran, G Kong, YH Chan… - …, 2023 - thelancet.com
Background Malnutrition and obesity are interdependent pathologies along the same
spectrum. We examined global trends and projections of disability-adjusted life years …

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

B Chong, G Kong, K Shankar, HSJ Chew, C Lin, R Goh… - Metabolism, 2023 - Elsevier
Background A significant proportion of premature deaths globally are related to metabolic
diseases in young adults. We examined the global trends and mortality of metabolic …

Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis

EEL Cho, CZ Ang, J Quek, CE Fu, LKE Lim, ZEQ Heng… - Gut, 2023 - gut.bmj.com
Introduction Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver
disease, with type 2 diabetes mellitus (T2DM) as a major predictor. Insulin resistance and …

Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

B Tan, XH Pan, HSJ Chew, RSJ Goh, C Lin… - International Journal of …, 2023 - nature.com
Background Recent studies suggest that tirzepatide, a dual glucose-dependent
insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has …

[HTML][HTML] Resmetirom: an orally administered, smallmolecule, liver-directed, β-selective THR agonist for the treatment of non-alcoholic fatty liver disease and non …

G Karim, MB Bansal - touchREVIEWS in Endocrinology, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty liver disease,
including non-alcoholic fatty liver (NAFL) and its more progressive form, non-alcoholic …

Zanthoxylum bungeanum amides ameliorates nonalcoholic fatty liver via regulating gut microbiota and activating AMPK/Nrf2 signaling

W Peng, CX He, RL Li, D Qian, LY Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Zanthoxylum bungeanum Maxim.(Rutaceae) is a
known herbal medicine with various bioactivities, including anti-obesity, lipid-lowering …

Towards precision medicine in non-alcoholic fatty liver disease

SM Francque - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden
vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and …