In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

The goal of a virus particle is to transport its genome in a replication-competent form from an
infected cell to an uninfected cell. To enter a new host cell, the majority of viruses take …

Animal cells harbour multiple innate effector mechanisms that inhibit virus replication. For
the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include …

The interferon-inducible myxovirus resistance (Mx) proteins play important roles in
combating a wide range of virus infections. MxA inhibits many RNA and DNA viruses …

The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-
cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …

Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide
crucial functions for lentiviral nuclear entry and integration. We previously showed that the …

Human immunodeficiency virus type 1 (HIV-1) infection is highly dependent on its capsid.
The capsid is a large container, made of∼ 1,300 proteins with altogether 4 million atoms …

The RNA genome of human immunodeficiency virus type 1 (HIV-1) is enclosed by a capsid
shell that dissociates within the cell in a multistep process known as uncoating, which …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …