Microglia: agents of the CNS pro-inflammatory response

JA Rodríguez-Gómez, E Kavanagh… - Cells, 2020 - mdpi.com
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes

R Yang, B Yang, W Liu, C Tan, H Chen… - Journal of …, 2023 - Springer
Neuroinflammation has been implicated in the initiation and progression of several central
nervous system (CNS) disorders, including Alzheimer's disease, Parkinson's disease …

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

C Madore, Q Leyrolle, L Morel, M Rossitto… - Nature …, 2020 - nature.com
Abstract Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the
brain. Westernization of dietary habits in both developed and developing countries is …

Reformulating pro-oxidant microglia in neurodegeneration

J García-Revilla, IM Alonso-Bellido… - Journal of Clinical …, 2019 - mdpi.com
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress
are central events. Recent genome-wide transcriptomic analyses of microglial cells under …

Roles of fatty acids in microglial polarization: evidence from in vitro and in vivo studies on neurodegenerative diseases

Sanjay, M Park, HJ Lee - International Journal of Molecular Sciences, 2022 - mdpi.com
Microglial polarization to the M1 phenotype (classically activated) or the M2 phenotype
(alternatively activated) is critical in determining the fate of immune responses in …

Impact of long-term supplementation with fish oil in individuals with non-alcoholic fatty liver disease: a double blind randomized placebo controlled clinical trial

K Cansanção, M Citelli, N Carvalho Leite… - Nutrients, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease affecting up to 25% of the
population worldwide. n-3 long-chain polyunsaturated fatty acids (n-3 PUFA) have been …

Omega-3 polyunsaturated fatty acids alleviate early brain injury after traumatic brain injury by inhibiting neuroinflammation and necroptosis

Y Wu, J Zhang, X Feng, W Jiao - Translational Neuroscience, 2023 - degruyter.com
Presently, traumatic brain injury (TBI) is a leading contributor to disability and mortality that
places a considerable financial burden on countries all over the world. Docosahexaenoic …

DHA attenuated Japanese Encephalitis virus infection-induced neuroinflammation and neuronal cell death in cultured rat Neuron/glia

CY Chang, CC Wu, JD Wang, JR Li, YY Wang… - Brain, Behavior, and …, 2021 - Elsevier
Abstract Japanese Encephalitis Virus (JEV) is a neurotropic virus and its Central Nervous
System (CNS) infection causes fatal encephalitis with high mortality and morbidity. Microglial …

脊髓损伤再生修复中的问题与挑战

田婷, 李晓光 - 中国组织工程研究, 2021 - cjter.com
摘要背景: 脊髓损伤导致严重的感觉, 运动功能障碍, 反射异常以及自主神经功能紊乱.
目前脊髓损伤尚无有效的临床治疗措施. 近年来, 研究人员开发出多种新型治疗方案 …

Neuroprotective effect of the Nrf2/ARE/miRNA145-5p signaling pathway in the early phase of spinal cord injury

N Ebrahimy, N Gasterich, V Behrens, J Amini… - Life sciences, 2022 - Elsevier
Aims Spinal cord injury (SCI) is a debilitating neurological condition often associated with
chronic neuroinflammation and redox imbalance. Oxidative stress is one of the main …