[HTML][HTML] Redox control of senescence and age-related disease
A Chandrasekaran, MPS Idelchik, JA Melendez - Redox biology, 2017 - Elsevier
The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …
pathologies has captured the scientific community's attention for decades. While many …
Senescence-messaging secretome: SMS-ing cellular stress
T Kuilman, DS Peeper - Nature reviews cancer, 2009 - nature.com
Oncogene-induced cellular senescence constitutes a strong anti-proliferative response,
which can be set in motion following either oncogene activation or loss of tumour suppressor …
which can be set in motion following either oncogene activation or loss of tumour suppressor …
[HTML][HTML] Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
S Özcan, N Alessio, MB Acar, E Mert, F Omerli… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to
carry out several functions, such as sensitizing surrounding cells to senesce; …
carry out several functions, such as sensitizing surrounding cells to senesce; …
[HTML][HTML] MicroRNA-34a: the bad guy in age-related vascular diseases
A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
Signaling pathways of the insulin-like growth factor binding proteins
RC Baxter - Endocrine Reviews, 2023 - academic.oup.com
The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …
proteins that modulate cell signaling through multiple pathways. Their canonical function at …
[HTML][HTML] Factors and pathways modulating endothelial cell senescence in vascular aging
Aging causes a progressive decline in the structure and function of organs. With advancing
age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of …
age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of …
Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular …
A Villaret, J Galitzky, P Decaunes, D Esteve… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage,
susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We …
susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We …
Oncogene-induced senescence: the bright and dark side of the response
VG Gorgoulis, TD Halazonetis - Current opinion in cell biology, 2010 - Elsevier
In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since
then large leaps in understanding this phenomenon have been achieved. There is …
then large leaps in understanding this phenomenon have been achieved. There is …
[HTML][HTML] Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
Accumulation of senescent cells contributes to age-related diseases including idiopathic
pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins (IGFBPs) regulate many …
pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins (IGFBPs) regulate many …
[HTML][HTML] Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
V Severino, N Alessio, A Farina, A Sandomenico… - Cell death & …, 2013 - nature.com
Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …