The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Oncogene-induced cellular senescence constitutes a strong anti-proliferative response,
which can be set in motion following either oncogene activation or loss of tumour suppressor …

Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to
carry out several functions, such as sensitizing surrounding cells to senesce; …

The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

Aging causes a progressive decline in the structure and function of organs. With advancing
age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of …

OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage,
susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We …

In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since
then large leaps in understanding this phenomenon have been achieved. There is …

Accumulation of senescent cells contributes to age-related diseases including idiopathic
pulmonary fibrosis (IPF). Insulin-like growth factor binding proteins (IGFBPs) regulate many …

Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …