Abstract Ataxia‐telangiectasia (A‐T) is an autosomal recessive primary immunodeficiency
(PID) disease that is caused by mutations in ataxia‐telangiectasia mutated (ATM) gene …

Background Ataxia-telangiectasia is an autosomal recessive, multi-system, and life-
shortening disease caused by mutations in the ataxia-telangiectasia mutated gene …

Objective To assess the cancer risk in children and adolescents following exposure to low
dose ionising radiation from diagnostic computed tomography (CT) scans. Design …

The genetic and environmental components in 15 common cancers were estimated using
the nationwide Swedish Family‐Cancer Database. Tetrachoric correlations were used to …

The prevalence of germ line mutations in non‐BRCA 1/2 genes associated with hereditary
breast cancer (BC) is low, and the role of some of these genes in BC predisposition and …

Background: Homozygous or compound heterozygous mutations in the ATM gene are the
principal cause of ataxia telangiectasia (AT). Several studies have suggested that …

This paper summarizes current knowledge on ionizing radiation-associated breast cancer in
the context of established breast cancer risk factors, the radiation dose–response …

In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic
counselling purposes, it is important to allow for the fact that other breast cancer …

One of the most important risk factors for breast cancer is family history of the disease,
indicating that genetic factors are important determinants of breast cancer risk. A number of …

ATM was originally identified by positional cloning as the gene that underlies the autosomal
recessive condition ataxia-telangiectasia. The encoded protein plays a central role in the …