The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …

Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage
disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate autophagic genes by …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

To the Editor—The recent breakthroughs in the development of optical nanoscopy have
provided unprecedented views of the inner workings of cells. Stimulated emission depletion …