PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
DNA damage: from threat to treatment
A Carusillo, C Mussolino - Cells, 2020 - mdpi.com
DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
RAD51 Gene Family Structure and Function
B Bonilla, SR Hengel, MKK Grundy… - Annual review of …, 2020 - annualreviews.org
Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
Diverse role of survival motor neuron protein
RN Singh, MD Howell, EW Ottesen… - Biochimica et Biophysica …, 2017 - Elsevier
Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …
The oncogenic roles and clinical implications of YAP/TAZ in breast cancer
J Luo, H Zou, Y Guo, T Tong, Y Chen, Y Xiao… - British Journal of …, 2023 - nature.com
Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of
cancer-related deaths among women worldwide. Yes-associated protein (YAP) and …
cancer-related deaths among women worldwide. Yes-associated protein (YAP) and …
RAD-ical new insights into RAD51 regulation
MR Sullivan, KA Bernstein - Genes, 2018 - mdpi.com
The accurate repair of DNA is critical for genome stability and cancer prevention. DNA
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …
Role of Rad51 and DNA repair in cancer: A molecular perspective
The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …
Regulation and pharmacological targeting of RAD51 in cancer
MKK Grundy, RJ Buckanovich, KA Bernstein - NAR cancer, 2020 - academic.oup.com
Regulation of homologous recombination (HR) is central for cancer prevention. However,
too little HR can increase cancer incidence, whereas too much HR can drive cancer …
too little HR can increase cancer incidence, whereas too much HR can drive cancer …
Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms
ZS Lima, M Ghadamzadeh, FT Arashloo… - Journal of hematology & …, 2019 - Springer
Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …
background of women contributes to her risk of having breast cancer. Certain inherited DNA …