Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Growing evidence suggests that ceramides play an important role in the development of
atherosclerotic and valvular heart disease. Ceramides are biologically active sphingolipids …

Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and
other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on …

Sphingolipids are bioactive molecules that play either pro-and anti-atherogenic roles in the
formation and maturation of atherosclerotic plaques. Among SLs, ceramide and sphingosine …

Recent works indicate that the lipid composition of extracellular vesicles (EVs) can modify
their biological functions and their incorporation into recipient cells. In particular high‐fat …

Background Cardiovascular disease (CVD) remains the leading cause of death worldwide.
The main driving force behind this association is coronary artery disease (CAD), the …

Abstract Neutral sphingomyelinase‐2 (nSMase2), gene name sphingomyelin
phosphodiesterase‐3 (Smpd3), is a key regulatory enzyme responsible for generating the …

This study investigated the potential protective effects of alpha‐mangostin (α‐MG) on
ultraviolet B (UVB)‐induced damage in HaCaT cells. The results showed that α‐MG less …

Membrane lipids extensively modulate the activation gating of voltage-gated potassium
channels (KV), however, much less is known about the mechanisms of ceramide and …

Background Ceramides have recently been identified as novel biomarkers associated with
diabetes mellitus (DM) and major adverse cardiac and cerebrovascular events (MACCE) …