Purpose To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR)
development and the current treatment for PVR prevention. Methods A PubMed search was …

Purpose: Proliferative vitreoretinopathy (PVR) occurs in 5%–10% of rhegmatogenous retinal
detachment cases and is the principle cause for failure of retinal reattachment surgery …

Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a key
fibrosis pathogenesis in proliferative vitreoretinopathy (PVR). However, few medicines can …

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of
prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual …

Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is
involved in various biological functions and many signaling networks, interacting with extra …

This study was aim to investigate whether the progression of proliferative vitreoretinopathy
(PVR) depended on the activation of Yesassociated protein (YAP) and the subsequent …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
released from the extracellular and intracellular space of damaged tissue or dead cells …

In this study, we report that AZD6738 (Ceralasertib), a novel potent ataxia telangiectasia and
Rad3-related (ATR) kinase inhibitor, can decrease intraocular pressure (IOP) and inhibits …

Proliferative vitreoretinopathy (PVR) is an intractable condition after rhegmatogenous retinal
detachment (RD), which is the primary cause of failure in retinal reattachment surgery. This …

The purpose of this study was to investigate whether excessive extracellular matrix (ECM)
deposition-induced mechanical matrix stiffness plays a key role in promoting retinal pigment …