With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Abstract Background Guanine quadruplexes (GQs) play vital roles in many cellular
processes and are of much interest as drug targets. In contrast to the availability of many …

RNA has an important role not only as the messenger of genetic information but also as a
regulator of gene expression. Given its central role in cell biology, there is significant interest …

G-quadruplexes have raised considerable interest during the past years for the development
of therapies against cancer. These noncanonical structures of DNA may be found in …

Guanine quadruplexes (G4s) are non-canonical nucleic acids structures common in
important genomic regions. Parallel-stranded G4 folds are the most abundant, but their …

The noncanonical guanine-rich DNAs have drawn particular attention to the scientific world
due to their controllable diverse and polymorphic structures. Apart from biological and …

G-quadruplexes (GQs) are key noncanonical DNA and RNA architectures stabilized by
desolvated monovalent cations present in their central channels. We analyze extended …

Molecular dynamics (MD) simulations are coming of age in the study of nucleic acids,
including specific tertiary structures such as G-quadruplexes. While being precious for …

Abstract 7SK RNA, as part of the 7SK ribonucleoprotein complex, is crucial to the regulation
of transcription by RNA-polymerase II, via its interaction with the positive transcription …

The reversible folding of the thrombin-binding DNA aptamer G-quadruplexes (GQs)(TBA-15)
starting from fully unfolded states was demonstrated using a prolonged time scale (10–12 …