This text presents a unified treatment of experimental designs and design concepts
commonly used in practice. It connects the objectives of research to the type of experimental …

Purpose The continued emergence of multidrug resistant bacterial infections and the decline
in discovery of new antibiotics are major challenges for health care throughout the world …

BACKGROUND Celastrol is one of several bioactive compounds extracted from the
medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and …

The orphan receptor GPR18 has become a research target following the discovery of a
putative endogenous agonist, N-arachidonoyl glycine (NAGly). Chemical similarity between …

Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks
secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities …

Background Parkinson's disease (PD) is associated with proteostasis disturbances and
accumulation of misfolded α‐synuclein (α‐syn), a cytosolic protein present in high …

Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …

Microglia are brain macrophages and play beneficial and/or detrimental roles in many brain
pathologies because of their inflammatory and phagocytic activity. Microglial inflammation …

Herein, we report a platform to integrate customizable quantities of catechol units into
polymers by reacting caffeic acid carbonic anhydride with polymers having pendant amine …

Histone deacetylase (HDAC) inhibitors prevent neural cell death in in vivo models of
cerebral ischaemia, brain injury and neurodegenerative disease. One mechanism by which …