Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

Abstract Human Papillomaviruses (HPVs) are double-stranded DNA viruses, that infect
epithelial cells and are etiologically involved in the development of human cancer. Today …

The potential roles of epigenetic alterations in the pathogenesis of autoimmune rheumatic
diseases are raising great expectations among clinicians and researchers. Epigenetic …

The retinoblastoma (RB) tumor suppressor is recognized as a master regulator that controls
entry into the S phase of the cell cycle. Its loss leads to uncontrolled cell proliferation and is a …

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to
repair these cytotoxic lesions can result in genome rearrangements conducive to the …

Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA
replication and chromosome distribution but also the ability to sense and repair …

Epigenetic marks change during fetal development, adult life, and aging. Some changes
play an important role in the establishment and regulation of gene programs, but others …

Recent studies have revealed that chromatin remodeling, caused by DNA methylation and
histone modifications such as acetylation, methylation, and phosphorylation, plays a pivotal …

VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …