The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for
mortality. The epithelium is key in understanding the pathobiology as it is specialized to …

Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In
pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and …

Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and
mucous membranes with high morbidity and potentially lethal outcome. The major clinical …

Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist
mechanical stress because they adopt a strongly adhesive state in which they are said to be …

Desmosomes are intercellular junctions that tether intermediate filaments to the plasma
membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate …

The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …

Pemphigus, Bullous Impetigo, and the Staphylococcal Scalded-Skin Syndrome | New England
Journal of Medicine Skip to main content Access provided byMGH The New England Journal of …

Desmosomes are highly specialized anchoring junctions that link intermediate filaments to
sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding …