For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar
process involving ER tubules encircling and constricting mitochondria. The force for …

Formins are highly conserved proteins that have essential roles in remodelling the actin and
microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work …

Intracellular transport is vital for the function, survival and architecture of every eukaryotic
cell. Long-range transport in animal cells is thought to depend exclusively on microtubule …

Cells require actin nucleators to catalyze the de novo assembly of filaments and actin
elongation factors to control the rate and extent of polymerization. Nucleation and elongation …

Various cellular processes (including cell motility) are driven by the regulated, polarized
assembly of actin filaments into distinct force-producing arrays of defined size and …

In cells the de novo nucleation of actin filaments from monomers requires actin-nucleating
proteins. These fall into three main families–the Arp2/3 complex and its nucleation …

Oocytes mature into eggs by extruding half of their chromosomes in a small cell termed the
polar body. Asymmetric oocyte division is essential for fertility [1], but despite its importance …

Vasodilator‐stimulated phosphoprotein (VASP) is a key regulator of dynamic actin structures
like filopodia and lamellipodia, but its precise function in their formation is controversial …